Evaluation of Hyypoglycemic and Hypolipidemic Activity of Nyctanthes Arbortristis Linn against Streptozotocin Induced Diabetic Rats

Abstract

Problem statement: The present study was aimed to explore the hypoglycemic and hypolipidemic activity of Nyctanthes arbortristis linn roots against Streptozotocin (STZ) induced experimental rats. Approach: Ethanolic extract of roots of Nyctanthes arbortristis was administered to streptozotocin induced rats.Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Nyctanthes arbortristis (200 mg kg^-1 b.wt) in diabetic groups. Blood glucose levels were determined on 0, 7th, 14th, 21st and 28th day after oral administration of ethanolic extracts of Nyctanthes arbortristis (200 mg kg^-1). Results: An ethanolic extract of Nyctanthes arbortristis was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Nyctanthes arbortristis on serum lipid profile like Total Cholesterol, triglycerides, low density, very low density and high density lipoprotein were also measured in the diabetic and non diabetic rats. There was significant reduction in Total Cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. Conclusion: We concluded that Nyctanthes arbortristis possesses a hypoglycemic and hypolipidemic effect.