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ISSN: 1557-4962 (Print)
ISSN: 1557-4970 (Online)
Research Article Open Access

Antispasmodic Activity of Persea cordata Vell. Mez. (Lauraceae) Fractions on Guinea Pig Ileum Induced by 5-Hydroxytryptamine and Bradykinin

Júlio A. Zampirolo1, Hellen K. Stulzer1, Monika Piazzon Tagliari1, Valfredo Schlemper2 and Valdir Cechinel-Filho1
  • 1 Itajaí Valley University (UNIVALI), Brazil
  • 2 Catarinense Plateu University (UNIPLAC), Brazil

Abstract

Problem statement: Persea cordata previously demonstrated antispasmodic action against two neurotransmitters. It is important confirm such action against other neurotransmitters. Approach: Present study described the antispasmodic activity of polar (EtOAc; n-BuOH) and non polar (n-hexane; dichloromethane) fractions from the bark of Persea cordata, against guinea pig ileum contracted by 5-hydroxytryptamine (5-HT) and bradykinin (BK). Results: The results indicated that hexane and dichloromethane fractions caused the most significant relaxant activity against both neurotransmitters tested. Conclusion: The effects seem to be related to the evidenced presence of steroids and terpenes, but additional studies were in progress to identify the active principles of this plant.

American Journal of Pharmacology and Toxicology
Volume 3 No. 4, 2008, 229-233

DOI: https://doi.org/10.3844/ajptsp.2008.229.233

Submitted On: 5 December 2008 Published On: 31 December 2008

How to Cite: Zampirolo, J. A., Stulzer, H. K., Tagliari, M. P., Schlemper, V. & Cechinel-Filho, V. (2008). Antispasmodic Activity of Persea cordata Vell. Mez. (Lauraceae) Fractions on Guinea Pig Ileum Induced by 5-Hydroxytryptamine and Bradykinin . American Journal of Pharmacology and Toxicology, 3(4), 229-233. https://doi.org/10.3844/ajptsp.2008.229.233

Open AccessCopyright: © 2008 Júlio A. Zampirolo, Hellen K. Stulzer, Monika Piazzon Tagliari, Valfredo Schlemper and Valdir Cechinel-Filho. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Persea cordata
  • antispasmodic activity
  • guinea pig ileum
  • terpenes and steroids