Anti-hyperglycaemic and Anti-obesity Effects of Capparis spinosa and Chamaemelum nobile Aqueous Extracts in HFD Mice

Abstract

This study was undertaken in order to evaluate the possible anti-hyperglycaemic and body weight reducing activities of the aqueous extract of both Capparis spinosa (CS) and Chamaemelum nobile (CN) (20 mg/kg^-1). The results demonstrate clearly that repeated oral administration of both CS and CN aqueous extract evoked a potent anti-hyperglycaemic activity in high fat diet (HFD) obese mice. Postprandial hyperglycaemic peaks were significantly lower in plant-treated experimental groups. In other hand, body weight was significantly lower in CS and CN-treated groups when compared to the control one after daily oral administration of CS and CN aqueous extracts for 15 days. We can conclude that these plants evoked potent anti-hyperglycaemic and anti-obesity effects. This fact could support their use by the Moroccan population for diabetes control and treatment.